Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.60 |
| ▸ | HTR2B | P41595 | 5/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CD44 | P16070 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5944522 | 0.81 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| Hydrochloric Acid SCHEMBL5944489 | 0.80 | PNMT (0.97) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL29941551 | 0.76 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL1487047 | 0.76 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL28147038 | 0.75 | HTR2C (0.60) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| Hydrochloric Acid SCHEMBL1038022 | 0.75 | PNMT (0.97) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL28014241 | 0.74 | HTR2C (0.83) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL2401511 | 0.73 | PNMT (0.71) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL11483387 | 0.73 | PNMT (0.71) | PNMTADRA2AADRA2BADRA2CHTR2C | |
| SCHEMBL1885004 | 0.73 | PNMT (0.71) | PNMTADRA2AADRA2BADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |