Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | CASP1 | P29466 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 8/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000122 | 0.78 | KDM4E (0.69) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3005577 | 0.75 | KDM4E (1.00) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3242208 | 0.73 | FFAR3 (0.70) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3002415 | 0.73 | KDM4E (0.77) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3007058 | 0.73 | KDM4E (0.74) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3003468 | 0.69 | KDM4E (0.79) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3329777 | 0.68 | ALDH1A1 (0.78) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL16211041 | 0.68 | SMN1; SMN2 (0.73) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL3324655 | 0.68 | SMN1; SMN2 (0.72) | KDM4EHSD17B10CASP1ALDH1A1HPGD | |
| SCHEMBL12784576 | 0.67 | ALDH1A1 (0.64) | KDM4EHSD17B10CASP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |