Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004053 | 0.85 | HSD17B10 (0.66) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3326098 | 0.83 | KDM4E (0.80) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3250425 | 0.80 | FFAR3 (0.70) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL2998592 | 0.79 | KDM4E (1.00) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3324020 | 0.76 | KDM4E (0.78) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3320570 | 0.75 | KDM4E (0.75) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL7817207 | 0.74 | HSD17B10 (0.65) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3249509 | 0.73 | KDM4E (0.61) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL7010448 | 0.69 | KDM4E (0.56) | FFAR3KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL2993652 | 0.69 | ALDH1A1 (0.51) | FFAR3KDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |