Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29045009 | 0.81 | ALDH1A1 (0.54) | HTTL3MBTL1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL528358 | 0.76 | ALDH1A1 (0.52) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10873736 | 0.74 | ALDH1A1 (0.50) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1045139 | 0.74 | ALDH1A1 (0.58) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL26128842 | 0.74 | ALDH1A1 (0.53) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6696083 | 0.74 | ALDH1A1 (0.61) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL824071 | 0.74 | ALDH1A1 (0.53) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1520510 | 0.72 | ALDH1A1 (0.52) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL672369 | 0.72 | ALDH1A1 (0.52) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7919473 | 0.72 | ALDH1A1 (0.52) | HTTL3MBTL1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255616-B1 | PROCESS FOR THE PRODUCTION OF STRONGLY ADHERENT SURFACE-COATINGS BY PLASMA-OR CORONAACTIVATED GRAFTING | BASF SE (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2005089957-A1 | PROCESS FOR THE PRODUCTION OF STRONGLY ADHERENT COATINGS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-09-29 | — | — | WO | disclosed |
| US-6733847-B2 | DEPOSITION OF ELECTRON- OR H-DONORS HAVING AT LEAST ONE ETHYLENICALLY UNSATURATED GROUP ON A PLASMA-ACTIVATED SUBSTRATE, CURING BY IONIZATION RADIATION OR ELECTROMAGNETIC ENERGY | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-05-11 | — | — | US | disclosed |
| US-20030129322-A1 | Process for the production of strongly adherent surface-coatings by plasma-activated grafting | CIBA SPECIALTY CHEMICALS CORP. | 2003-07-10 | — | — | US | disclosed |
| EP-1255616-A2 | PROCESS FOR THE PRODUCTION OF STRONGLY ADHERENT SURFACE-COATINGS BY PLASMA-ACTIVATED GRAFTING | Ciba SC Holding AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001058971-A2 | PROCESS FOR THE PRODUCTION OF STRONGLY ADHERENT SURFACE-COATINGS BY PLASMA-ACTIVATED GRAFTING | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-08-16 | — | — | WO | disclosed |