Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147478 | 0.88 | KCNH2 (0.54) | KCNH2SMN1; SMN2MAPTNPC1KDM4E | |
| SCHEMBL3249035 | 0.86 | KCNH2 (0.48) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL3251533 | 0.85 | KCNH2 (0.49) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL3256694 | 0.84 | KCNH2 (0.49) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL3246763 | 0.82 | KCNH2 (0.47) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL3252103 | 0.80 | KCNH2 (0.38) | KCNH2ALDH1A1 | |
| SCHEMBL3255856 | 0.80 | KCNH2 (0.47) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL1147947 | 0.78 | KCNH2 (0.52) | KCNH2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1147476 | 0.78 | KCNH2 (0.52) | KCNH2SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1147433 | 0.76 | KCNH2 (0.53) | KCNH2SMN1; SMN2ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001478-B1 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-02 | — | — | EP | claimed |