Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL324720 | 0.99 | ALDH1A1 (0.60) | ALDH1A1KMT2AL3MBTL1OPRL1OPRM1 | |
| SCHEMBL12503128 | 0.77 | ALDH1A1 (0.39) | ALDH1A1KMT2ALMNAMIFGAA | |
| SCHEMBL325375 | 0.76 | SLC6A2 (0.45) | ALDH1A1KMT2AL3MBTL1LMNACNR2 | |
| SCHEMBL325002 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KMT2ACHRM2HTR1ADRD3 | |
| SCHEMBL11158619 | 0.70 | RPS6KB1 (0.54) | ALDH1A1KMT2AL3MBTL1LMNACNR2 | |
| SCHEMBL4152093 | 0.70 | SLC6A4 (0.60) | ALDH1A1KMT2AOPRL1OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL14815137 | 0.69 | ALDH1A1 (0.52) | ALDH1A1KMT2AL3MBTL1OPRL1OPRM1 | |
| SCHEMBL4575599 | 0.68 | IDO1 (0.43) | KMT2AOPRM1OPRK1LMNACACNA1C | |
| SCHEMBL4135481 | 0.67 | MEN1 (0.66) | ALDH1A1KMT2AOPRL1OPRM1OPRD1 | |
| SCHEMBL1281621 | 0.66 | MEN1 (0.65) | KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | claimed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | claimed |
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | disclosed |