SCHEMBL325002

SCHEMBL325002

Clc1ccc(C(c2nnn[nH]2)N2CCOCC2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
P4HB P07237 1/20 0.46
SMAD3 P84022 1/20 0.46
CYP2D6 P10635 2/20 0.45
CYP19A1 P11511 1/20 0.45
MAPT P10636 4/20 0.40
HRH3 Q9Y5N1 2/20 0.40
HTT P42858 1/20 0.40
ACHE P22303 1/20 0.40
SLC6A9 P48067 1/20 0.39
CHRM2 P08172 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
BCL2 P10415 1/20 0.38
CHRM1 P11229 1/20 0.38
DRD1 P21728 1/20 0.38
TBXA2R P21731 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
ADRA1A P35348 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12503222 0.86 CYP2D6 (0.47) ALDH1A1CYP2D6CYP19A1MAPTHRH3
SCHEMBL325375 0.85 SLC6A2 (0.45) ALDH1A1P4HBSMAD3MAPTHRH3
SCHEMBL324172 0.84 CYP2D6 (0.67) P4HBCYP2D6CYP19A1HRH3SLC6A9
SCHEMBL323778 0.83 CHRM2 (0.58) ALDH1A1CYP2D6CYP19A1HRH3SLC6A9
SCHEMBL327686 0.81 CYP2D6 (0.43) ALDH1A1CYP2D6CYP19A1MAPTHRH3
SCHEMBL16769334 0.80 ALDH1A1 (0.62) ALDH1A1P4HBSMAD3CYP2D6CYP19A1
SCHEMBL323776 0.78 CYP3A4 (0.61) ALDH1A1CYP2D6CYP19A1HRH3SLC6A9
SCHEMBL325153 0.77 CYP3A4 (0.48) ALDH1A1CYP2D6CYP19A1MAPTHRH3
SCHEMBL324763 0.74 CYP3A4 (0.45) ALDH1A1CYP2D6CYP19A1HRH3SLC6A9
SCHEMBL325009 0.74 ALDH1A1 (0.61) ALDH1A1CHRM2HTR1ADRD3NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2590953-A1 TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS Convergence Pharmaceuticals Limited (GB) 2013-05-15 EP claimed
WO-2012004604-A1 TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS Convergence Pharmaceuticals Limited (GB) 2012-01-12 WO claimed
EP-2590953-A1 TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS Convergence Pharmaceuticals Limited (GB) 2013-05-15 EP disclosed
WO-2012004604-A1 TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS Convergence Pharmaceuticals Limited (GB) 2012-01-12 WO disclosed