Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 13/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249326 | 1.00 | CCR1 (0.55) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL2200099 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL14703475 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2200706 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2201838 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL2200251 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL13620885 | 0.90 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656152 | 0.88 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL6859704 | 0.87 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL3244941 | 0.86 | CCR1 (0.74) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669356-B1 | CCR1 Antagonists for the treatment of i.a demyelinating inflammatory disease | MILLENNIUM PHARM INC (US) | 2010-05-19 | — | — | EP | claimed |