Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249059 | 0.93 | MAPT (0.47) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3254878 | 0.92 | PKM (0.52) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3243020 | 0.92 | PKM (0.48) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3251980 | 0.92 | HSD17B10 (0.45) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3253968 | 0.91 | PKM (0.49) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3249676 | 0.91 | POLB (0.47) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3248794 | 0.91 | MEN1 (0.58) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3245542 | 0.88 | ALDH1A1 (0.42) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3249858 | 0.88 | HSD17B10 (0.42) | HSD17B10MAPK1ALDH1A1HPGDMEN1 | |
| SCHEMBL3261788 | 0.88 | HIF1A (0.45) | HSD17B10MAPK1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |