Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 16/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861133 | 0.86 | CCR1 (0.48) | CCR1CHRM2CCR5 | |
| SCHEMBL5703572 | 0.81 | CCR1 (0.58) | CCR1CHRM2CCR5 | |
| SCHEMBL14579859 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL12301342 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL655061 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL655060 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656424 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656423 | 0.79 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL12936669 | 0.79 | CCR1 (0.49) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL656152 | 0.79 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1669356-B1 | CCR1 Antagonists for the treatment of i.a demyelinating inflammatory disease | MILLENNIUM PHARM INC (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-1669356-A1 | CCR1 Antagonists for the treatment of i.a demyelinating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-06-14 | — | — | EP | disclosed |