Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 17/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18896009 | 0.88 | CCR1 (0.48) | CCR1CHRM2CCR5 | |
| SCHEMBL18895978 | 0.84 | CCR1 (0.47) | CCR1CHRM2CCR5 | |
| SCHEMBL15478333 | 0.80 | DRD2 (0.40) | CCR1 | |
| SCHEMBL15478356 | 0.80 | CCR1 (0.35) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL3250560 | 0.79 | CCR1 (0.50) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL15478400 | 0.79 | CCR1 (0.37) | CCR1CHRM2CCR5HRH1 | |
| SCHEMBL15478355 | 0.78 | CCR1 (0.38) | CCR1 | |
| SCHEMBL15478359 | 0.78 | CCR1 (0.38) | CCR1HRH1 | |
| SCHEMBL15478375 | 0.78 | CCR1 (0.50) | CCR1CHRM2HRH1 | |
| SCHEMBL656423 | 0.77 | CCR1 (0.77) | CCR1CHRM2CCR5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| EP-2286811-A1 | Chemokine receptor antagonists and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2011-02-23 | — | — | EP | disclosed |