Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21816218 | 0.81 | CDK8 (0.51) | APOBEC3AAPOBEC3GADORA3KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL9089313 | 0.80 | CDK8 (0.50) | APOBEC3AAPOBEC3GADORA3KDM4ENPC1 | |
| SCHEMBL496758 | 0.74 | NPC1 (0.60) | ADORA3KDM4ENPC1RAB9APTGS1 | |
| SCHEMBL14740144 | 0.74 | CDK8 (0.40) | APOBEC3AAPOBEC3GADORA3KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL21834227 | 0.73 | NPC1 (0.59) | ADORA3KDM4ENPC1RAB9APTGS1 | |
| SCHEMBL18237866 | 0.72 | ADORA3 (0.43) | APOBEC3AAPOBEC3GADORA3KDM4EMEN1 | |
| SCHEMBL2814544 | 0.70 | PKM (0.52) | KDM4EALDH1A1DYRK1AHPGD | |
| SCHEMBL6286800 | 0.69 | KDM4E (0.43) | ADORA3KDM4ELMNANPC1RAB9A | |
| SCHEMBL19153793 | 0.68 | ADORA3 (0.42) | ADORA3KDM4ELMNAMEN1KMT2A | |
| SCHEMBL5487220 | 0.68 | ADORA3 (0.42) | APOBEC3AAPOBEC3GADORA3KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |