Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9996467 | 0.84 | PDE2A (0.44) | PDE2AALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL384969 | 0.80 | AR (0.47) | PDE2APTGDR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16951053 | 0.80 | PDE2A (0.41) | PDE2APTGDR2ALDH1A1MEN1TSHR | |
| SCHEMBL2651995 | 0.80 | PTGDR2 (0.43) | PDE2APTGDR2ALDH1A1MEN1TSHR | |
| SCHEMBL2515789 | 0.80 | PTGDR2 (0.43) | PDE2APTGDR2ALDH1A1MEN1TSHR | |
| SCHEMBL29837271 | 0.80 | AR (0.47) | PDE2APTGDR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9996392 | 0.78 | CES2 (0.46) | PDE2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL5545019 | 0.75 | PTGDR2 (0.40) | PDE2APTGDR2ALDH1A1MEN1TSHR | |
| SCHEMBL9996732 | 0.73 | AR (0.49) | — | |
| SCHEMBL980201 | 0.73 | TSHR (0.61) | PDE2AALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773330-B1 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME (US) | 2010-05-26 | — | — | EP | disclosed |