Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254312 | 0.90 | MAPT (0.52) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3248447 | 0.88 | HSD11B1 (0.47) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3256465 | 0.88 | KMT2A (0.47) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3248435 | 0.87 | SMN1; SMN2 (0.50) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3253280 | 0.87 | HSD11B1 (0.48) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3255832 | 0.87 | HSD11B1 (0.52) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3255322 | 0.84 | ALDH1A1 (0.56) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3254379 | 0.84 | HSD11B1 (0.48) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3256545 | 0.84 | HSD11B1 (0.51) | GAALMNAHSD11B1ALDH1A1HTT | |
| SCHEMBL3251270 | 0.83 | HSD11B1 (0.52) | GAALMNAHSD11B1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |