Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 1.00 |
| ▸ | ADRB3 known ✓ | P13945 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | MTOR | P42345 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoproterenol SCHEMBL29519146 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Levisoprenaline SCHEMBL29620666 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL4165 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL29386243 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Levisoprenaline SCHEMBL250806 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL4166 | 1.00 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL7627 | 0.98 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Levisoprenaline SCHEMBL4745572 | 0.98 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL6151626 | 0.98 | MAPT (0.97) | MAPTADRB2TDP1KDM4EADRB1 | |
| Isoproterenol SCHEMBL3672791 | 0.98 | MAPT (1.00) | MAPTADRB2TDP1KDM4EADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722562-B2 | Combinatorial analysis and repair | IMMUDEX APS (DK) | 2020-07-28 | — | — | US | disclosed |
| EP-2490670-B1 | COMPOSITION FOR INHALATION | INNOVATA LTD (GB) | 2019-04-17 | — | — | EP | disclosed |
| WO-2010009735-A2 | COMBINATORIAL ANALYSIS AND REPAIR | DAKO DENMARK A/S (DK) | 2010-01-28 | — | — | WO | disclosed |
| EP-1539177-A2 | COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE | Crackower, Michael A. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004026285-A2 | COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE | AMGEN CANADA INC. (CA) | 2004-04-01 | — | — | WO | disclosed |
| WO-2001021767-A9 | PLURIPOTENT EMBRYONIC-LIKE STEM CELLS, COMPOSITIONS, METHODS AND USES THEREOF | MORPHOGEN PHARMACEUTICALS INC (US) | 2002-12-27 | — | — | WO | disclosed |
| EP-1218489-A2 | PLURIPOTENT EMBRYONIC-LIKE STEM CELLS, COMPOSITIONS, METHODS AND USES THEREOF | Morphogen Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021767-A2 | PLURIPOTENT EMBRYONIC-LIKE STEM CELLS, COMPOSITIONS, METHODS AND USES THEREOF | MORPHOGEN PHARMACEUTICALS, INC. (US) | 2001-03-29 | — | — | WO | disclosed |
| EP-0767778-A1 | 1-PHENOXY-3-N-ALKYLAMINOPROPAN-2-OL HALOGEN DERIVATIVES USEFUL AS MYOCARDIAL $g(b) ADRENERGIC RECEPTOR MARKERS AND AS $g(b)-BLOCKING AGENTS | CIS BIO INTERNATIONAL (FR) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000717-A1 | 1-PHENOXY-3-N-ALKYLAMINOPROPAN-2-OL HALOGEN DERIVATIVES USEFUL AS MYOCARDIAL β ADRENERGIC RECEPTOR MARKERS AND AS β-BLOCKING AGENTS | CIS BIO INTERNATIONAL (FR) | 1996-01-11 | — | — | WO | disclosed |
| US-5316907-A | Enzymatic fluorometric assay for adenylate cyclase | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1994-05-31 | — | — | US | disclosed |
| US-4263323-A | β-Receptor blocking compounds and treatment of cardiovascular disorders therewith | AKTIEBOLAGET HASSLE (SE) | 1981-04-21 | — | — | US | disclosed |
| US-4263325-A | PHENOXY- AMINE DERIVATIVES | AKTIEBOLAGET HASSLE (SE) | 1981-04-21 | — | — | US | disclosed |
| US-4073909-A | ADRENERGIC BLOCKING AGENTS, HYPOGLYCEMIC AGENTS, ANTILIPEMIC AGENTS | SANDOZ LTD. (CH) | 1978-02-14 | — | — | US | disclosed |