Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795781 | 0.80 | HTR1A (0.50) | OPRM1HTR2CHTR1A | |
| SCHEMBL3246830 | 0.79 | BCHE (0.54) | BCHE | |
| SCHEMBL3245093 | 0.78 | CA1 (0.49) | OPRM1HTR2CBCHEOPRK1 | |
| SCHEMBL917364 | 0.76 | ALDH1A1 (0.52) | OPRM1OPRK1 | |
| SCHEMBL3253489 | 0.75 | BCHE (0.53) | BCHE | |
| SCHEMBL3243959 | 0.74 | CA1 (0.48) | OPRM1HTR2CBCHEOPRK1 | |
| SCHEMBL918901 | 0.73 | ALDH1A1 (0.51) | OPRM1OPRK1 | |
| SCHEMBL23959518 | 0.72 | HTR2C (0.45) | OPRM1HTR2CDYRK1ADRD1PTPRCAP | |
| SCHEMBL30422600 | 0.72 | HTR2C (0.45) | OPRM1HTR2CDYRK1ADRD1PTPRCAP | |
| SCHEMBL24174623 | 0.72 | HTR2C (0.45) | OPRM1HTR2CDYRK1ADRD1PTPRCAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |