Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | SNCA | P37840 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708822 | 0.91 | PDE7A (0.36) | HTTMAPTMEN1KMT2AKDM4E | |
| SCHEMBL3254604 | 0.90 | MAPT (0.39) | HTTMAPTMEN1KMT2AKDM4E | |
| SCHEMBL3253737 | 0.88 | L3MBTL1 (0.41) | HTTMAPTMEN1KMT2AKDM4E | |
| SCHEMBL916535 | 0.87 | APP (0.37) | APPSNCAHTTMAPTMEN1 | |
| SCHEMBL710143 | 0.86 | CNR1 (0.47) | APPSNCAHTTMAPTMEN1 | |
| SCHEMBL916466 | 0.86 | SMN1; SMN2 (0.41) | APPSNCAHTTMAPTMEN1 | |
| SCHEMBL710094 | 0.84 | PDE7A (0.36) | SNCAHTTMAPTMEN1KMT2A | |
| SCHEMBL917044 | 0.84 | HTT (0.38) | APPSNCAHTTMAPTMEN1 | |
| SCHEMBL10131506 | 0.84 | HTT (0.38) | APPSNCAHTTMAPTMEN1 | |
| SCHEMBL916327 | 0.84 | HTT (0.38) | HTTMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |