Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254071 | 0.90 | APP (0.40) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL708822 | 0.90 | PDE7A (0.36) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL3253737 | 0.88 | L3MBTL1 (0.41) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL711641 | 0.88 | MAPT (0.38) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL710094 | 0.86 | PDE7A (0.36) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL709751 | 0.86 | MAPT (0.47) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL708821 | 0.86 | CNR1 (0.44) | MAPTALDH1A1HTTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL710238 | 0.85 | MAPT (0.46) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL13356741 | 0.83 | CYP19A1 (0.42) | ALDH1A1HTTMEN1KMT2ACYP19A1 | |
| SCHEMBL915440 | 0.83 | MAPT (0.39) | MAPTALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-B1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | ORGANON NV (NL) | 2010-05-26 | — | — | EP | disclosed |