SCHEMBL3254378

SCHEMBL3254378

O=c1oc(-c2ccc(-c3nc4ccccc4c(=O)o3)cc2)nc2ccccc12.[NaH]

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 2/20 0.89
NPC1 O15118 5/20 0.81
RAB9A P51151 4/20 0.81
RXFP1 Q9HBX9 1/20 0.81
ALDH1A1 P00352 8/20 0.74
KDM4E B2RXH2 6/20 0.74
MAPT P10636 4/20 0.74
SMN1; SMN2 Q16637 3/20 0.74
LMNA P02545 1/20 0.74
KMT2A Q03164 2/20 0.72
L3MBTL1 Q9Y468 2/20 0.72
MEN1 O00255 1/20 0.72
TP53 P04637 3/20 0.68
F2 P00734 2/20 0.67
HPGD P15428 3/20 0.64
XBP1 P17861 1/20 0.62
GAA P10253 1/20 0.62
C1R P00736 4/20 0.61
NPSR1 Q6W5P4 1/20 0.61
PLG P00747 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29456973 0.98 ELANE (0.93) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL125184 0.98 ELANE (0.93) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL12212888 0.96 ELANE (0.89) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL273036 0.95 ELANE (0.93) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL29382161 0.94 ELANE (1.00) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL272702 0.94 ELANE (1.00) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL914482 0.90 NPC1 (1.00) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL913962 0.90 ELANE (0.78) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL10325841 0.90 NPC1 (1.00) ELANENPC1RAB9ARXFP1ALDH1A1
SCHEMBL30084714 0.90 ELANE (0.78) ELANENPC1RAB9ARXFP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1438352-B1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME CYTEC TECH CORP (US) 2010-05-26 EP disclosed
US-6774232-B2 FOR USE IN HIGH TRANSPARENCY APPLICATIONS; TO PREVENT DEGRADATION CAUSED BY SUNLIGHT AND OTHER SOURCES OF ULTRAVIOLET (UV) RADIATION OF POLYMERIC MATERIALS CYTEC TECHNOLOGY CORP. 2004-08-10 US disclosed
EP-1438352-A1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME Cytec Technology Corp. (US) 2004-07-21 EP disclosed
US-20030096889-A1 Low color, low sodium benzoxazinone UV absorbers and process for making same CYTEC TECHNOLOGY CORP. 2003-05-22 US disclosed
WO-2003035735-A1 LOW COLOR, LOW SODIUM BENZOXAZINONE UV ABSORBERS AND PROCESS FOR MAKING SAME CYTEC TECHNOLOGY CORP. (US) 2003-05-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030096889-A1 Low color, low sodium benzoxazinone UV absorbers and process for making same XDH, SI, CA4 ELANE 2200/4885NPC1 1663/4885RAB9A 2948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.