Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261788 | 0.93 | HIF1A (0.45) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL3264336 | 0.92 | HIF1A (0.47) | BRD4TP53MAPTAURKAAURKB | |
| SCHEMBL3241975 | 0.91 | MEN1 (0.49) | BRD4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3255514 | 0.91 | MEN1 (0.45) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL3250772 | 0.91 | HTT (0.42) | BRD4MEN1KMT2AHTR6ALDH1A1 | |
| SCHEMBL3250519 | 0.91 | BRD4 (0.50) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL3253042 | 0.91 | HIF1A (0.47) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL3253968 | 0.91 | PKM (0.49) | TP53MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3263281 | 0.91 | BRD4 (0.54) | BRD4TP53MAPTMEN1KMT2A | |
| SCHEMBL3254501 | 0.91 | ITK (0.41) | BRD4TP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |