Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264336 | 0.92 | HIF1A (0.47) | BRD4MEN1ALDH1A1HPGDALOX15 | |
| SCHEMBL3250772 | 0.91 | HTT (0.42) | ITKBRD4MEN1ALDH1A1HPGD | |
| SCHEMBL3255483 | 0.91 | BRD4 (0.50) | BRD4MEN1ALDH1A1HPGDALOX15 | |
| SCHEMBL3254912 | 0.90 | BRD4 (0.53) | BRD4MEN1ALDH1A1HPGDALOX15 | |
| SCHEMBL3252939 | 0.90 | BRD4 (0.45) | ITKBRD4MEN1ALDH1A1HPGD | |
| SCHEMBL3243020 | 0.89 | PKM (0.48) | MEN1ALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL3245542 | 0.88 | ALDH1A1 (0.42) | MEN1ALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL3249858 | 0.88 | HSD17B10 (0.42) | MEN1ALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL3261788 | 0.88 | HIF1A (0.45) | BRD4MEN1ALDH1A1HPGDALOX15 | |
| SCHEMBL3263281 | 0.87 | BRD4 (0.54) | BRD4MEN1ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |