Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192323 | 0.86 | HRH4 (0.33) | PDE4B | |
| SCHEMBL3128295 | 0.85 | PDE4B (0.42) | PDE4BGAAMAPTGRM2CYP3A4 | |
| SCHEMBL3201858 | 0.85 | HRH4 (0.35) | — | |
| SCHEMBL3122554 | 0.85 | PDE4B (0.44) | PDE4BGAAMAPTGRM2CYP3A4 | |
| SCHEMBL3217097 | 0.84 | HRH4 (0.34) | — | |
| SCHEMBL3200789 | 0.80 | PDE4B (0.40) | PDE4BGAAMAPTGRM2NR3C2 | |
| SCHEMBL3214297 | 0.77 | PDE4B (0.42) | PDE4BMAPT | |
| SCHEMBL1157700 | 0.75 | PDE4B (0.44) | PDE4BGRM2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3123568 | 0.75 | ALDH1A1 (0.40) | PDE4BGAAMAPTCYP3A4CYP1A2 | |
| SCHEMBL3120759 | 0.74 | GRM2 (0.40) | PDE4BGRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |