Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | TNF | P01375 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201876 | 0.87 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL6629030 | 0.87 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL201231 | 0.86 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL17531862 | 0.82 | NPC1 (0.65) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL212263 | 0.81 | CYP2C9 (0.71) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL16809339 | 0.80 | RAB9A (0.76) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL1980717 | 0.80 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL22790006 | 0.79 | PIK3CA (0.65) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL2756796 | 0.79 | NPC1 (0.59) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 | |
| SCHEMBL202825 | 0.79 | HDAC6 (0.62) | PIK3CAPIK3CBPIK3CGPI4KBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |