Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863547 | 0.82 | MAPT (0.52) | S1PR4S1PR1S1PR3S1PR5THRA | |
| SCHEMBL3257434 | 0.76 | S1PR1 (0.43) | S1PR4S1PR1S1PR3S1PR5THRA | |
| SCHEMBL9885402 | 0.71 | S1PR1 (0.58) | S1PR4S1PR1S1PR3S1PR5THRA | |
| SCHEMBL2869515 | 0.71 | MAPT (0.57) | S1PR1THRATHRBNPC1POLB | |
| SCHEMBL3257536 | 0.71 | S1PR1 (0.49) | S1PR1THRATHRBMAPT | |
| SCHEMBL4656709 | 0.70 | MAPT (0.64) | S1PR4S1PR1S1PR3S1PR5THRA | |
| SCHEMBL3260301 | 0.70 | S1PR1 (0.49) | S1PR4S1PR1S1PR3S1PR5THRA | |
| SCHEMBL3258918 | 0.70 | S1PR1 (0.50) | S1PR1THRATHRBNPC1RAB9A | |
| SCHEMBL3257407 | 0.70 | S1PR1 (0.50) | S1PR4S1PR1S1PR5THRATHRB | |
| SCHEMBL3150783 | 0.67 | THRA (0.44) | S1PR4S1PR1S1PR3S1PR5THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747196-B1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2010-02-10 | — | — | EP | claimed |