Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | C5 | P01031 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 7/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9885402 | 0.88 | S1PR1 (0.58) | MAPTHSD17B10S1PR1S1PR3S1PR4 | |
| SCHEMBL13338000 | 0.86 | S1PR1 (0.54) | MAPTHSD17B10S1PR1S1PR3S1PR4 | |
| SCHEMBL26554065 | 0.84 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5THRA | |
| SCHEMBL12164847 | 0.81 | S1PR4 (0.52) | MAPTHSD17B10S1PR1S1PR3S1PR4 | |
| SCHEMBL28203083 | 0.79 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5THRA | |
| SCHEMBL4401762 | 0.78 | MAPT (0.57) | MAPTHSD17B10S1PR1S1PR3S1PR4 | |
| SCHEMBL6512897 | 0.77 | MAPK1 (0.59) | MAPTALDH1A1 | |
| SCHEMBL9440250 | 0.76 | THRA (0.67) | S1PR1S1PR3S1PR4S1PR5THRA | |
| SCHEMBL23554170 | 0.76 | ALDH1A1 (0.69) | S1PR1S1PR3FAAHALDH1A1 | |
| SCHEMBL9503837 | 0.76 | ALDH1A1 (0.69) | S1PR1S1PR3FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996565-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | Achillion Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007103550-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | ACHILLION PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | disclosed |