SCHEMBL3257764

SCHEMBL3257764

Clc1cccnc1C(Cl)(Cl)Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.39
LMNA P02545 4/20 0.36
KDM4E B2RXH2 2/20 0.36
HSP90AA1 P07900 2/20 0.36
MAPT P10636 2/20 0.36
TSHR P16473 1/20 0.36
CCR1 P32246 1/20 0.36
CCR8 P51685 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
BRD4 O60885 1/20 0.36
METAP2 P50579 1/20 0.36
METAP1 P53582 1/20 0.36
DPP4 P27487 1/20 0.36
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
KMT2A Q03164 2/20 0.35
HTT P42858 2/20 0.35
CYP2C19 P33261 1/20 0.35
MEN1 O00255 1/20 0.35
ALOX15B O15296 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30592740 1.00 TDP1 (0.39) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL10354554 0.84 CYP19A1 (0.35) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL10850555 0.84 CYP19A1 (0.35) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL29760844 0.81 TRPV1 (0.37) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL2035613 0.81 TRPV1 (0.37) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL179292 0.81 TRPV1 (0.37) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL10354989 0.78 KDM4E (0.32) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL18668145 0.78 HSD11B1 (0.39) TDP1LMNAKDM4EHSP90AA1MAPT
SCHEMBL369947 0.78 TRPV1 (0.35) TDP1NFE2L2
SCHEMBL1334085 0.78 LMNA (0.36) TDP1LMNAKDM4EHSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106146125-A A kind of complete element compound fertilizer for garden 蒋华 2016-11-23 CN claimed
CN-86105880-A The recirculation of catalyzer in liquid phase halogen exchange reaction 1988-03-23 CN claimed
CN-86108662-A From Halogenated Pyridine Compounds, remove iron(ic) chloride 1987-09-09 CN claimed
EP-0092117-B1 PROCESS FOR PRODUCING CHLORONICOTINIC ACID COMPOUNDS ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-07-15 EP claimed
US-4577027-A Production of polychlorinated pyridine mixtures by direct liquid phase chlorination of alpha-picoline KALAMA CHEMICAL, INC. (US) 1986-03-18 US claimed
US-4564681-A Production of mixtures rich in 3-chloro-2-trichloromethyl pyridine KALAMA CHEMICAL, INC. (US) 1986-01-14 US claimed
EP-0009212-B1 PROCESS FOR PRODUCING 2-CHLORO-5-TRICHLOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA LTD. (JP) 1984-02-08 EP claimed
JP-9176121-A None JP disclosed
JP-8099956-A None JP disclosed
CN-116715387-A Production process of herbicide clopyralid 安徽海顺化工有限公司 2023-09-08 CN disclosed
CN-110195239-B Method for preparing aldehyde and acid by electrochemical dechlorination of polychlorinated methyl pyridine derivative 浙江工业大学 2020-08-14 CN disclosed
CN-110195238-B Method for preparing amide by electrochemical dechlorination of trichloromethylpyridine derivative 浙江工业大学 2020-08-14 CN disclosed
CN-110172710-B Method for preparing carboxylic ester by electrochemical dechlorination of trichloromethylpyridine derivative 浙江工业大学 2020-08-14 CN disclosed
EP-0005064-B1 PROCESS FOR PREPARING 2,3,5,6-TETRACHLOROPYRIDINE THE DOW CHEMICAL COMPANY (US) 1984-10-10 EP disclosed
EP-0009212-B1 PROCESS FOR PRODUCING 2-CHLORO-5-TRICHLOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA LTD. (JP) 1984-02-08 EP disclosed
US-4256894-A REACTING LIQUID CHLORO-SUBSTITUTED (TRICHLOROMETHYL) PYRIDINE WITH CHLORINE IN THE PRESENCE OF A LEWIS ACID CATALYST THE DOW CHEMICAL COMPANY (US) 1981-03-17 US disclosed
EP-0021453-A2 2-Chloro-5-trichloromethylpyridine IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-01-07 EP disclosed
US-4227001-A LEWIS ACID CATALYST THE DOW CHEMICAL COMPANY (US) 1980-10-07 US disclosed
EP-0007160-A1 Preparation of polychlorinated pyridines from 2,4-dichloro-6-(trichloromethyl)pyridine THE DOW CHEMICAL COMPANY (US) 1980-01-23 EP disclosed
EP-0005064-A1 Process for preparing 2,3,5,6-tetrachloropyridine THE DOW CHEMICAL COMPANY (US) 1979-10-31 EP disclosed