Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339292 | 0.77 | ALDH1A1 (0.34) | ALDH1A1GAAHSD17B10SMN1; SMN2EP300 | |
| SCHEMBL1337155 | 0.69 | DPP4 (0.34) | KDM4ELMNAMAPK1PDE4BHPGD | |
| SCHEMBL11864616 | 0.59 | MEN1 (0.40) | EP300CREBBPMEN1KMT2A | |
| SCHEMBL1586652 | 0.59 | KMT2A (0.54) | ALDH1A1HSD17B10EP300CREBBPKDM4E | |
| SCHEMBL13985724 | 0.59 | KMT2A (0.47) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL9680069 | 0.59 | MEN1 (0.46) | ALDH1A1EP300CREBBPLMNAHPGD | |
| SCHEMBL20847153 | 0.58 | ALDH1A1 (0.51) | ALDH1A1GAAHSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL23952258 | 0.58 | MEN1 (0.39) | ALDH1A1SMN1; SMN2EP300CREBBPLMNA | |
| SCHEMBL14745252 | 0.58 | MEN1 (0.42) | CREBBPPDE4BHPGDMEN1KMT2A | |
| SCHEMBL7686383 | 0.57 | KMT2A (0.39) | ALDH1A1SMN1; SMN2CREBBPLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-B1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-07-21 | — | — | EP | disclosed |