Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.57 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.57 |
| ▸ | ITGAL | P20701 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | ADK | P55263 | 1/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazoline SCHEMBL29356169 | 0.82 | EGFR (1.00) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL22833783 | 0.82 | EGFR (1.00) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL29490398 | 0.82 | EGFR (1.00) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL5920 | 0.82 | EGFR (1.00) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL11972093 | 0.80 | EGFR (0.67) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| SCHEMBL3196932 | 0.80 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL3533306 | 0.80 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL1119374 | 0.80 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL21055790 | 0.80 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL4487630 | 0.80 | EGFR (0.95) | EGFRPIK3CDPIK3CATDO2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778312-B | Organic material containing indoloquinazolinedione heterocyclic structure and application thereof | 北京燕化集联光电技术有限公司 | 2022-12-02 | — | — | CN | claimed |
| CN-109136319-B | Method for improving microbial production of indole quinazoline active alkaloid compound and application | 中山大学 | 2021-07-13 | — | — | CN | claimed |
| CN-112778312-A | Organic material containing indoloquinazolinedione heterocyclic structure and application thereof | 北京燕化集联光电技术有限公司 | 2021-05-11 | — | — | CN | claimed |
| CN-109136319-A | A kind of method and application for improving microorganism and producing indole quinazoline class active bio alkali cpd | 中山大学 | 2019-01-04 | — | — | CN | claimed |
| CN-103288827-B | A kind of preparation method and activity of new indole quinazoline Alkaloid | INSTITUTE OF BOTANY,JIANGSU PROVINCE AND CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-25 | — | — | CN | claimed |
| US-20140037561-A1 | COMPOSITION AND METHODS OF ENHANCED SKIN CELL TURNOVER | RUKU HOLDINGS, LLC | 2014-02-06 | — | — | US | claimed |
| CN-103288827-A | Preparation method and activity of novel indole quinazoline alkaloid | INST BOTANY JIANGSU PROVINCE & CAS | 2013-09-11 | — | — | CN | claimed |
| WO-2012105982-A1 | SKIN RENEWAL ENHANCER | KULESZA JOHN E (US) | 2012-08-09 | — | — | WO | claimed |
| CN-102399221-A | Application of diindoloquinazoline alkaloid in preparation of antitumor drugs and antifungal drugs | INST BOTANY JIANGSU PROVINCE & CAS | 2012-04-04 | — | — | CN | claimed |
| CN-102093357-A | Novel indoletriazole alkaloid as well as preparation method and antifungal application thereof | INST BOTANY JIANGSU PROVINCE & CAS | 2011-06-15 | — | — | CN | claimed |
| US-7655659-B2 | Biomimetic of Evodia rutaecarpa fruit extract for amelioration of inflammation | APPLIED GENETICS INCORPORATED DERMATICS (US) | 2010-02-02 | — | — | US | claimed |
| US-20080096902-A1 | Biomimetic Of Evodia Rutaecarpa Fruit Extract For Amelioration Of Inflammation | APPLIED GENETICS INCORPORATED DERMATICS (US) | 2008-04-24 | — | — | US | claimed |
| CN-101005856-A | Biomimetic of evodia rutaecarpa fruit extract for amelioration of inflammation | APPLIED GENETICS INC DERMATICS (US) | 2007-07-25 | — | — | CN | claimed |
| EP-1784225-A2 | BIOMIMETIC OF EVODIA RUTAECARPA FRUIT EXTRACT FOR AMELIORATION OF INFLAMMATION | Applied Genetics Incorporated Dermatics (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006023377-A2 | BIOMIMETIC OF EVODIA RUTAECARPA FRUIT EXTRACT FOR AMELIORATION OF INFLAMMATION | APPLIED GENETICS INCORPORATED DERMATICS (US) | 2006-03-02 | — | — | WO | claimed |
| CN-117257808-B | Application of rutaecarpine in preparation of product for promoting wound healing | 广州市朝利良生物科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-117257808-A | Application of rutaecarpine in preparation of product for promoting wound healing | 广州市朝利良生物科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| US-20030082631-A1 | Compounds modulating PPAR-gamma | BIOVITRUM AB (SE) | 2003-05-01 | — | — | US | disclosed |
| US-20030073862-A1 | Compounds | BIOVITRUM AB (SE) | 2003-04-17 | — | — | US | disclosed |
| WO-2003004458-A1 | NEW COMPOUNDS | BIOVITRUM AB (SE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030082631-A1 | Compounds modulating PPAR-gamma | PPARG, PPARA, PPARD | EGFR 863/4885TRPA1 740/4885CA1 4735/4885 |
| US-20030073862-A1 | Compounds | PPARG, PPARA, PPARD | EGFR 1207/4885TRPA1 929/4885CA1 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.