Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 12/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282487 | 0.91 | PDE10A (0.38) | PLK1AMY1AHDAC6 | |
| SCHEMBL4286273 | 0.81 | PLK1 (0.39) | PLK1PLK3IKBKECDK2AMY1A | |
| SCHEMBL4357514 | 0.81 | CHEK2 (0.42) | PLK1PLK3 | |
| SCHEMBL3255726 | 0.79 | PLK1 (0.63) | PLK1PLK3IKBKECDK2 | |
| SCHEMBL4278526 | 0.79 | ACHE (0.41) | PLK1 | |
| SCHEMBL4280900 | 0.77 | AMY1A (0.42) | AMY1AHDAC6 | |
| SCHEMBL3259644 | 0.75 | PDE10A (0.38) | HDAC6 | |
| SCHEMBL4283167 | 0.74 | SCD (0.41) | — | |
| SCHEMBL13440060 | 0.74 | PLK1 (0.53) | PLK1PLK3IKBKECDK2 | |
| SCHEMBL3251823 | 0.74 | PLK1 (0.53) | PLK1PLK3IKBKECDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032563-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON PLK | GLAXOSMITHKLINE LLC (US) | 2010-06-02 | — | — | EP | disclosed |