Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261499 | 0.81 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL3259389 | 0.78 | PTGS1 (0.42) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL7459363 | 0.70 | — | — | |
| Benzene SCHEMBL27682221 | 0.69 | CYP2A6 (0.45) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| Benzene SCHEMBL27682124 | 0.67 | KCNH2 (0.43) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL16983116 | 0.66 | KCNH2 (0.50) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL532194 | 0.65 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL532193 | 0.65 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL16348305 | 0.65 | IDO1 (0.44) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL21741529 | 0.65 | KCNH2 (0.47) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678014-B | Heterocyclic kinase modulators | SGX PHARMACEUTICALS INC | 2012-12-12 | — | — | CN | disclosed |
| CN-101678014-A | heterocyclic kinase modulators | SGX PHARMACEUTICALS INC | 2010-03-24 | — | — | CN | disclosed |
| EP-2162132-A1 | HETEROCYCLIC KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20090156594-A1 | HETEROCYCLIC KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2009-06-18 | — | — | US | disclosed |
| WO-2008144767-A1 | HETEROCYCLIC KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156594-A1 | HETEROCYCLIC KINASE MODULATORS | MAP3K20, MAP4K2, MAP3K13 | PIK3CA 251/4885PIK3CD 227/4885PIK3CB 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.