Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 4/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3269226 | 0.81 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL17247571 | 0.79 | GAA (0.61) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL17247577 | 0.76 | GAA (0.57) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL2365151 | 0.74 | ALDH1A1 (1.00) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL9153141 | 0.72 | GAA (0.96) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL359437 | 0.71 | ALDH1A1 (0.52) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL17817456 | 0.71 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL15884808 | 0.71 | ALDH1A1 (0.51) | ALDH1A1GAAMAPTTHRBSHMT2 | |
| SCHEMBL359186 | 0.71 | ALDH1A1 (0.51) | ALDH1A1GAAMAPTTHRBMGLL | |
| SCHEMBL360695 | 0.71 | ALDH1A1 (0.51) | ALDH1A1GAAMAPTTHRBMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100376568-C | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2008-03-26 | — | — | CN | claimed |
| EP-1618104-B1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2007-06-20 | — | — | EP | claimed |
| CN-1774436-A | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2006-05-17 | — | — | CN | claimed |
| EP-1618104-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | Evultis (CH) | 2006-01-25 | — | — | EP | claimed |
| WO-2004092159-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2004-10-28 | — | — | WO | claimed |
| US-7678923-B2 | Method for synthesizing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | EVULTIS (CH) | 2010-03-16 | — | — | US | disclosed |
| CN-100376568-C | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2008-03-26 | — | — | CN | disclosed |
| CN-100376568-C | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2008-03-26 | — | — | CN | disclosed |
| US-20070155811-A1 | Method for synthesing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | EVULTIS (CH) | 2007-07-05 | — | — | US | disclosed |
| EP-1618104-B1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2007-06-20 | — | — | EP | disclosed |
| EP-1618104-B1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2007-06-20 | — | — | EP | disclosed |
| CN-1774436-A | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1774436-A | Synthesis method of 5-chloro-1-aryl-4- (4, 5-dicyano-1H-imidazole-2-yl) -3-alkyl-1H-pyrazole derivative | EVULTIS (CH) | 2006-05-17 | — | — | CN | disclosed |
| EP-1618104-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | Evultis (CH) | 2006-01-25 | — | — | EP | disclosed |
| EP-1618104-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | Evultis (CH) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004092159-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2004-10-28 | — | — | WO | disclosed |
| WO-2004092159-A1 | METHOD FOR SYNTHESISING 5-CHLORO-1-ARYL-4-(4, 5-DICYANO-1H-IMIDAZOL-2-YL)-3-ALKYL-1H-PYRAZOLE DERIVATIVES | EVULTIS (CH) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155811-A1 | Method for synthesing 5-chloro-1-aryl-4-(4,5-dicyano-1h-imidazol-2-yl)-3-alkyl-1h-pyrazole derivatives | CYP3A5, CYP4B1, AADAC | ALDH1A1 939/4885GAA 3655/4885MAPT 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.