Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Crotonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Crotonic Acid SCHEMBL5706213 | 1.00 | — | — | |
| Crotonic Acid SCHEMBL27718105 | 0.91 | — | — | |
| Crotonic Acid SCHEMBL10603685 | 0.88 | TSHR (0.44) | — | |
| Crotonic Acid SCHEMBL305485 | 0.88 | TSHR (0.44) | — | |
| Crotonic Acid SCHEMBL28429 | 0.87 | — | — | |
| Crotonic Acid SCHEMBL22034 | 0.87 | — | — | |
| Crotonic Acid SCHEMBL1428157 | 0.87 | TSHR (0.57) | — | |
| Crotonic Acid SCHEMBL22033 | 0.87 | — | — | |
| Crotonic Acid SCHEMBL167626 | 0.87 | TSHR (0.57) | — | |
| Crotonic Acid SCHEMBL1427547 | 0.87 | TSHR (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8821845-B2 | Concentrated ingredient for treating and/or modifying surfaces, and use thereof in cosmetic compositions | RHODIA CHIMIE (FR) | 2014-09-02 | — | — | US | disclosed |
| US-8680038-B2 | Copolymer containing zwitterionic units and other units, composition comprising the copolymer, and use | RHODIA OPERATIONS (FR) | 2014-03-25 | — | — | US | disclosed |
| US-8343520-B2 | For treating skin or hair; stability, transparency | RHODIA CHIMIE (FR) | 2013-01-01 | — | — | US | disclosed |
| US-20120183590-A1 | Cosmetic Composition Comprising An Ampholytic Copolymer | RHODIA OPERATIONS (FR) | 2012-07-19 | — | — | US | disclosed |
| US-7846423-B2 | Cosmetic composition comprising a block copolymer | RHODIA CHIMIE (FR) | 2010-12-07 | — | — | US | disclosed |
| US-20100061956-A1 | COSMETIC COMPOSITION COMPRISING AN AMPHOLYTIC COPOLYMER | RHODIA CHIMIE (FR) | 2010-03-11 | — | — | US | disclosed |
| US-20090304757-A1 | Cosmetic Compositions Comprising A Powdered Thermoplastic | RHODIA OPERATIONS (FR) | 2009-12-10 | — | — | US | disclosed |
| EP-1854843-B1 | Cosmetic composition comprising a block copolymer | RHODIA CHIMIE SA (FR) | 2009-09-09 | — | — | EP | disclosed |
| US-20090214608-A1 | POLYSACCHARIDE-BASED PRODUCTS WITH IMPROVED EASINESS OF USE, PROCESS TO MAKE THE SAME, AND APPLICATIONS OF THE SAME | RHODIA OPERATIONS (FR) | 2009-08-27 | — | — | US | disclosed |
| US-20090197791-A1 | COPOLYMER CONTAINING ZWITTERIONIC UNITS AND OTHER UNITS, COMPOSITION COMPRISING THE COPOLYMER, AND USE | RHODIA RECHERCHES ET TECHNOLOGIES (FR) | 2009-08-06 | — | — | US | disclosed |
| US-6660285-B2 | Using transparent aqueous cosmetic for rinsing, of at least one amphoteric as an agent for precipitating hydrosoluble or hydrodispersible cationic polymers derived from polysaccharides on dilution during application to the hair | RICCA JEAN-MARC (FR) | 2003-12-09 | — | — | US | disclosed |
| US-20030219397-A1 | Cosmetic composition comprising a block copolymer | RHODIA CHIMIE (FR) | 2003-11-27 | — | — | US | disclosed |
| US-20030139502-A1 | Cosmetic compositions comprising a cationic polymer/anionic surfactant mixture and use of said mixture as conditioning agent | RHODIA CHIMIE (FR) | 2003-07-24 | — | — | US | disclosed |
| WO-2003050184-A1 | COSMETIC COMPOSITION COMPRISING A BLOCK COPOLYMER | RHODIA CHIMIE (FR) | 2003-06-19 | — | — | WO | disclosed |
| US-20030086953-A1 | Use of amphoteric surfactants in cosmetic compositions to precipitate cationic polymers on dilution | RICCA JEAN-MARC (FR) | 2003-05-08 | — | — | US | disclosed |
| US-6509023-B1 | Mixture of trisiloxanes containing phenylalkyl or phenyl-alkenyl groups; emollient, vehicle and/or transfer resistance agent; skin, hair | Chimie, Rhodia (FR) | 2003-01-21 | — | — | US | disclosed |
| US-6475474-B1 | Use in cosmetic compositions of amphoteric surface-active agents for precipitating cationic polymers in the diluted state | RHODIA CHIMIE (FR) | 2002-11-05 | — | — | US | disclosed |
| US-6030630-A | Cosmetic compositions for the hair or skin based on sulfone copolyesters with polyorganosiloxane units | RHODIA CHIMIE (FR) | 2000-02-29 | — | — | US | disclosed |
| US-4648844-A | Dental lining composition | KURARAY CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| EP-0195690-A2 | Dental lining composition | KURARAY CO., LTD. (JP) | 1986-09-24 | — | — | EP | disclosed |