Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747216 | 1.00 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4747218 | 1.00 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL13841803 | 0.78 | TSHR (0.44) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4749340 | 0.77 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4749339 | 0.77 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL3263638 | 0.77 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4749610 | 0.77 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4749604 | 0.77 | HTT (0.40) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL13841807 | 0.74 | TMEM97 (0.36) | HTTPOLBCA1CA2CA7 | |
| SCHEMBL4080761 | 0.73 | LMNA (0.39) | POLBCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024772-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-03-04 | — | — | WO | disclosed |
| WO-2009053277-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2009-04-30 | — | — | WO | disclosed |
| WO-2008107365-A1 | NEW COMPOUNDS | MEDIVIR AB (SE) | 2008-09-12 | — | — | WO | disclosed |