Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.35 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749610 | 1.00 | HTT (0.40) | HTTNR1I2PGRADORA3OPRK1 | |
| SCHEMBL4749604 | 1.00 | HTT (0.40) | HTTNR1I2PGRADORA3OPRK1 | |
| SCHEMBL4749339 | 1.00 | HTT (0.40) | HTTNR1I2PGRADORA3OPRK1 | |
| SCHEMBL3263638 | 1.00 | HTT (0.40) | HTTNR1I2PGRADORA3OPRK1 | |
| SCHEMBL4747216 | 0.77 | HTT (0.40) | HTTCA1CA2CA7CA9 | |
| SCHEMBL4747218 | 0.77 | HTT (0.40) | HTTCA1CA2CA7CA9 | |
| SCHEMBL3261395 | 0.77 | HTT (0.40) | HTTCA1CA2CA7CA9 | |
| SCHEMBL4913763 | 0.75 | TBXAS1 (0.36) | HTT | |
| SCHEMBL13841803 | 0.75 | TSHR (0.44) | HTTCA1CA2CA7CA9 | |
| SCHEMBL24681155 | 0.75 | LMNA (0.44) | HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |