Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910262 | 0.93 | MAPT (0.58) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL2909909 | 0.88 | GAA (0.57) | SIRT6MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL10330200 | 0.76 | SIRT6 (0.78) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL77148 | 0.76 | SIRT6 (1.00) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL2913662 | 0.76 | SIRT6 (0.59) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL170932 | 0.75 | HPGD (0.75) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL2480696 | 0.75 | SIRT6 (0.71) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL2908099 | 0.75 | SIRT6 (0.60) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL2907565 | 0.73 | CSF1R (0.52) | SIRT6MAPTMAPK1RECQLKDM4E | |
| SCHEMBL30900326 | 0.72 | SIRT6 (0.67) | SIRT6MAPTALDH1A1HTR6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222298-A1 | USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER | Janssen Pharmaceutica N.V. (BE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009058801-A1 | USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |