Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 7/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520215 | 0.92 | SIRT6 (0.69) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL30858840 | 0.85 | MAPT (0.67) | SIRT6MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL520755 | 0.85 | MAPT (0.67) | SIRT6MAPTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL10330200 | 0.84 | SIRT6 (0.78) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL77148 | 0.84 | SIRT6 (1.00) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL13395270 | 0.80 | SIRT6 (0.54) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL14892360 | 0.79 | SIRT6 (0.89) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL30532598 | 0.79 | SIRT6 (0.75) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL27997682 | 0.79 | SIRT6 (0.75) | SIRT6MAPTALDH1A1HTR6MAPK1 | |
| SCHEMBL4723486 | 0.77 | L3MBTL1 (0.51) | SIRT6MAPTALDH1A1HTR6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |