Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 5/20 | 0.37 |
| ▸ | FLT1 | P17948 | 5/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | DUT | P33316 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372114 | 1.00 | ERBB2 (0.37) | ERBB2FLT1EPHA2KDREPHB4 | |
| SCHEMBL4939815 | 1.00 | ERBB2 (0.37) | ERBB2FLT1EPHA2KDREPHB4 | |
| SCHEMBL372074 | 0.75 | ERBB2 (0.38) | ERBB2FLT1EPHA2KDREPHB4 | |
| SCHEMBL337821 | 0.73 | — | — | |
| SCHEMBL337922 | 0.73 | — | — | |
| SCHEMBL372000 | 0.72 | ALDH1A1 (0.46) | ERBB2FLT1EPHA2KDREPHB4 | |
| SCHEMBL15327837 | 0.72 | ALDH1A1 (0.46) | ERBB2FLT1EPHA2KDREPHB4 | |
| SCHEMBL15755198 | 0.71 | DUT (0.32) | FKBP1ATOP2ADUT | |
| SCHEMBL3282024 | 0.69 | IRAK4 (0.36) | FKBP1ATOP2ADUT | |
| SCHEMBL21802067 | 0.69 | IRAK4 (0.36) | FKBP1ATOP2ADUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1874759-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1874759-A1 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108059-A1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2006-10-12 | — | — | WO | disclosed |