Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 5/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261461 | 0.85 | NUDT1 (0.44) | NUDT1JAK1EGLN2JAK3HRH3 | |
| SCHEMBL2250437 | 0.81 | NUDT1 (0.57) | NUDT1JAK1EGLN2JAK3JAK2 | |
| SCHEMBL2254109 | 0.79 | NUDT1 (0.60) | NUDT1JAK1EGLN2JAK3JAK2 | |
| SCHEMBL2253273 | 0.79 | NUDT1 (0.60) | NUDT1JAK1EGLN2JAK3JAK2 | |
| SCHEMBL2252271 | 0.78 | NUDT1 (0.46) | NUDT1JAK1EGLN2KDM4EMAPK1 | |
| SCHEMBL3262865 | 0.77 | NUDT1 (0.45) | NUDT1JAK1EGLN2JAK3HRH3 | |
| SCHEMBL25678808 | 0.76 | ADORA2A (0.46) | NUDT1JAK1JAK3KDM4EL3MBTL1 | |
| SCHEMBL3216262 | 0.75 | JAK1 (0.44) | NUDT1JAK1EGLN2JAK3JAK2 | |
| SCHEMBL25258926 | 0.72 | NUDT1 (0.41) | NUDT1JAK1JAK3 | |
| SCHEMBL25258924 | 0.72 | NUDT1 (0.41) | NUDT1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010187-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |