Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 4/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250437 | 0.86 | NUDT1 (0.57) | NUDT1EGLN2JAK1ALDH1A1CYP1A2 | |
| SCHEMBL2254109 | 0.84 | NUDT1 (0.60) | NUDT1EGLN2JAK1ALDH1A1CYP1A2 | |
| SCHEMBL2253273 | 0.84 | NUDT1 (0.60) | NUDT1EGLN2JAK1ALDH1A1CYP1A2 | |
| SCHEMBL2252271 | 0.83 | NUDT1 (0.46) | NUDT1EGLN2JAK1ALDH1A1NCF1 | |
| SCHEMBL3261461 | 0.81 | NUDT1 (0.44) | NUDT1EGLN2HRH3HRH4JAK1 | |
| SCHEMBL3591147 | 0.78 | NUDT1 (0.59) | NUDT1EGLN2JAK1HTR3EHTR3B | |
| SCHEMBL3262068 | 0.77 | NUDT1 (0.46) | NUDT1EGLN2HRH3HRH4JAK1 | |
| SCHEMBL3216262 | 0.76 | JAK1 (0.44) | NUDT1EGLN2JAK1ALDH1A1MTOR | |
| SCHEMBL4499154 | 0.72 | PRKCI (0.45) | HRH3HRH4HTR3AABCB1ADRB1 | |
| SCHEMBL18077197 | 0.72 | EGLN2 (0.62) | EGLN2ALDH1A1HTR2AADRB1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010187-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |