Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254913 | 0.91 | ABCC1 (0.43) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3257233 | 0.87 | ALDH1A1 (0.45) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3259092 | 0.85 | KMT2A (0.64) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3171306 | 0.82 | MEN1 (0.54) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3257449 | 0.81 | CA1 (0.46) | MEN1KMT2ANPC1RAB9AABCC1 | |
| SCHEMBL3259755 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3162328 | 0.76 | MEN1 (0.59) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL3167119 | 0.75 | ALDH1A1 (0.52) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL7497953 | 0.74 | EGFR (0.54) | MEN1KMT2ANPC1HTTSMN1; SMN2 | |
| SCHEMBL8088056 | 0.73 | EGFR (0.53) | ALDH1A1ABCG2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756110-B1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | SZOLCSANYI JANOS (HU) | 2010-03-31 | — | — | EP | disclosed |