Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262160 | 0.88 | HTT (0.45) | ALDH1A1MAPTHTTKMT2APIK3CG | |
| SCHEMBL7937768 | 0.75 | ADORA1 (0.53) | LRRK2ADORA1 | |
| SCHEMBL614711 | 0.68 | RET (0.61) | ALDH1A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2186588 | 0.66 | PIK3CG (0.60) | PIK3CGPIK3CDPIK3CAPIK3CBLRRK2 | |
| SCHEMBL936441 | 0.65 | PIK3CG (0.51) | ALDH1A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6181854 | 0.64 | HTT (0.47) | ALDH1A1MAPTHTTKMT2AOPRM1 | |
| SCHEMBL1933137 | 0.64 | PIK3CG (0.52) | ALDH1A1MAPTKMT2APIK3CGPIK3CD | |
| SCHEMBL3974032 | 0.64 | SMN1; SMN2 (0.54) | ALDH1A1MAPTHTTKMT2ANPC1 | |
| SCHEMBL10044580 | 0.63 | PIK3CG (0.44) | ALDH1A1KMT2APIK3CGPIK3CDPIK3CA | |
| SCHEMBL936292 | 0.63 | PIK3CD (0.61) | ALDH1A1PIK3CGPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020363-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |