Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262157 | 0.88 | ALDH1A1 (0.40) | HTTKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7937768 | 0.76 | ADORA1 (0.53) | LRRK2 | |
| SCHEMBL3974032 | 0.76 | SMN1; SMN2 (0.54) | HTTKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3305577 | 0.71 | ADORA1 (0.58) | HTTKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL614711 | 0.70 | RET (0.61) | ALDH1A1PIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2186588 | 0.67 | PIK3CG (0.60) | PIK3CGPIK3CDPIK3CAPIK3CBLRRK2 | |
| SCHEMBL936441 | 0.66 | PIK3CG (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL1819331 | 0.66 | HTT (0.60) | HTTKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1933137 | 0.65 | PIK3CG (0.52) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6181854 | 0.65 | HTT (0.47) | HTTKMT2AMAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020363-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |