⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26546183 | 0.80 | EPHX2 (0.53) | — | |
| SCHEMBL1259566 | 0.79 | — | — | |
| SCHEMBL4560098 | 0.79 | — | — | |
| SCHEMBL18072257 | 0.79 | — | — | |
| SCHEMBL13024156 | 0.79 | FFAR2 (0.58) | — | |
| SCHEMBL18964090 | 0.79 | KDM4E (0.46) | — | |
| SCHEMBL21743428 | 0.79 | KDM4E (0.45) | — | |
| Acetic Acid SCHEMBL27503512 | 0.78 | FFAR2 (0.40) | — | |
| SCHEMBL17186398 | 0.76 | EPHX2 (0.49) | — | |
| SCHEMBL25332354 | 0.75 | FFAR2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118922421-A | Bicyclic phthalazin-1 (2H) -one derivatives and related uses | 诺瑟拉有限公司 | 2024-11-08 | — | — | CN | disclosed |
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023187670-A1 | DIAZABICYCLOOCTANE DERIVATIVES USEFUL AS MATRIX METALLOPROTEINASE INHIBITORS | VASA THERAPEUTICS SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (PL) | 2023-10-05 | — | — | WO | disclosed |
| US-20210323960-A1 | FUSED TRI-CYCLIC COMPOUND AS PDE3/PDE4 DUAL INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2021-10-21 | — | — | US | disclosed |
| US-20210213014-A1 | METHODS OF USING EHMT2 INHIBITORS IN IMMUNOTHERAPIES | Epizyme, Inc. | 2021-07-15 | — | — | US | disclosed |
| EP-3822272-A1 | FUSED TRI-CYCLIC COMPOUND AS PDE3/PDE4 DUAL INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-05-19 | — | — | EP | disclosed |
| EP-3795568-A1 | FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2021-03-24 | — | — | EP | disclosed |
| EP-3265456-B1 | FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA INC (US) | 2020-11-18 | — | — | EP | disclosed |
| US-20200317642-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF | Epizyme, Inc. | 2020-10-08 | — | — | US | disclosed |
| CN-108863972-B | Oxazole amide derivative and preparation method and application thereof | 湖南大学 | 2020-08-04 | — | — | CN | disclosed |
| US-20080096887-A1 | cell proliferation, such as cancer, inflammation, and angiogenesis; fungal infections; antimalaria; Heat hock protein 90 (HSP-90) inhibitor | SERENEX, INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080096887-A1 | cell proliferation, such as cancer, inflammation, and angiogenesis; fungal infections; antimalaria; Heat hock protein 90 (HSP-90) inhibitor | SERENEX, INC. | 2008-04-24 | — | — | US | disclosed |
| US-7358370-B2 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | SERENEX, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358370-B2 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | SERENEX, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| EP-0143123-B1 | INDUSTRIAL PRODUCTS USEFUL AS INTERMEDIATES IN THE PREPARATION OF 4-HYDROXY-3 QUINOLEINE CARBOXAMIDE DERIVATIVES SUBSTITUTED AT POSITION 2, AND THE PREPARATION OF THESE INTERMEDIATES | ROUSSEL-UCLAF (FR) | 1990-07-25 | — | — | EP | disclosed |
| EP-0143123-A2 | Industrial products useful as intermediates in the preparation of 4-hydroxy-3 quinoleine carboxamide derivatives substituted at position 2, and the preparation of these intermediates | ROUSSEL-UCLAF (FR) | 1985-06-05 | — | — | EP | disclosed |
| US-4518775-A | Benzoxazine-4-one intermediates | ROUSSEL UCLAF (FR) | 1985-05-21 | — | — | US | disclosed |
| EP-0040573-B1 | 2-SUBSTITUTED-4-HYDROXY-3-QUINOLINECARBOXYLIC ACIDS, THEIR PREPARATION, THEIR USE AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES | ROUSSEL-UCLAF (FR) | 1984-08-01 | — | — | EP | disclosed |
| US-4397856-A | Analgesic 4-hydroxy-3-quinolinecarboxamides | ROUSSEL UCLAF (FR) | 1983-08-09 | — | — | US | disclosed |
| EP-0040573-A2 | 2-Substituted-4-hydroxy-3-quinolinecarboxylic acids, their preparation, their use as medicaments, compositions containing them and intermediates | ROUSSEL-UCLAF (FR) | 1981-11-25 | — | — | EP | disclosed |