Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144054 | 0.78 | NUDT1 (1.00) | NUDT1JAK2DYRK1AEGLN2JAK1 | |
| SCHEMBL3087585 | 0.77 | NUDT1 (0.69) | NUDT1JAK2EGLN2JAK1KDM4E | |
| SCHEMBL3104923 | 0.76 | NUDT1 (0.59) | NUDT1DYRK1AEGLN2JAK1 | |
| SCHEMBL10594428 | 0.76 | PIM1 (0.46) | NUDT1JAK2DYRK1ADYRK2KDM4E | |
| SCHEMBL3214727 | 0.76 | JAK2 (0.62) | JAK2DYRK1ADYRK2CCNA2CDK2 | |
| SCHEMBL3205602 | 0.74 | JAK2 (0.60) | JAK2JAK1KDM4E | |
| SCHEMBL3104872 | 0.74 | NUDT1 (0.69) | NUDT1JAK2DYRK1ADYRK2EGLN2 | |
| SCHEMBL13031278 | 0.74 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL3264207 | 0.73 | NUDT1 (0.72) | NUDT1JAK2EGLN2JAK1KDM4E | |
| SCHEMBL3215698 | 0.73 | NUDT1 (0.67) | NUDT1JAK2EGLN2JAK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160333011-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2016-11-17 | — | — | US | disclosed |
| US-9434732-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2016-09-06 | — | — | US | disclosed |
| US-8609687-B2 | Triazolopyridine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120225855-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | ZHU BING-YAN (US) | 2012-09-06 | — | — | US | disclosed |
| US-20100048557-A1 | Triazolopyridine JAK Inhibitor Compounds and Methods | GENENTECH, INC. | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048557-A1 | Triazolopyridine JAK Inhibitor Compounds and Methods | JAK2, JAK1, JAK3 | NUDT1 3080/4885JAK2 1/4885DYRK1A 16/4885 |
| US-20160333011-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK1, JAK2, JAK3 | NUDT1 2613/4885JAK2 2/4885DYRK1A 64/4885 |
| US-20120225855-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | NUDT1 3080/4885JAK2 1/4885DYRK1A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.