Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 8/20 | 0.64 |
| ▸ | NQO1 | P15559 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3480712 | 0.88 | NQO1 (0.67) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL1648184 | 0.84 | VKORC1 (0.72) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL3177583 | 0.82 | VKORC1 (0.69) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL3166280 | 0.82 | VKORC1 (0.62) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL13498415 | 0.81 | NQO1 (0.72) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL3171705 | 0.80 | VKORC1 (0.59) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL1647685 | 0.80 | VKORC1 (0.65) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL1649892 | 0.79 | NQO1 (0.79) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL29655586 | 0.79 | NQO1 (0.79) | VKORC1NQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL4589169 | 0.78 | VKORC1 (0.59) | VKORC1NQO1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161261-B1 | Materials and methods for treating coagulation disorders | ARMETHEON INC (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-2161261-A1 | Materials and methods for treating coagulation disorders | Aryx Therapeutics (US) | 2010-03-10 | — | — | EP | disclosed |