Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.80 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.71 |
| ▸ | F3 | P13726 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | KRAS | P01116 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | XDH | P47989 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | P4HB | P07237 | 1/20 | 0.63 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263021 | 1.00 | TNFRSF1A (0.80) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL8964940 | 0.89 | CTSL (0.74) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL31233066 | 0.89 | CTSL (0.74) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL8964944 | 0.89 | CTSL (0.74) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL5697763 | 0.89 | ABCG2 (0.73) | TNFRSF1ACXCL12ABCG2MEN1KMT2A | |
| SCHEMBL5697768 | 0.89 | ABCG2 (0.73) | TNFRSF1ACXCL12ABCG2MEN1KMT2A | |
| SCHEMBL15304468 | 0.89 | F3 (0.74) | TNFRSF1ACXCL12F3MEN1KMT2A | |
| SCHEMBL3219103 | 0.89 | TNFRSF1A (1.00) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL3219109 | 0.89 | TNFRSF1A (1.00) | TNFRSF1ACXCL12ABCG2F3MEN1 | |
| SCHEMBL8965097 | 0.88 | ABCG2 (0.68) | TNFRSF1ACXCL12ABCG2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552066-B2 | Modified chalcone compounds as antimitotic agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552066-B2 | Modified chalcone compounds as antimitotic agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20100222380-A1 | Modified Chalcone Compounds as Antimitotic Agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2010-09-02 | — | — | US | disclosed |
| US-7714025-B2 | Modified chalcone compounds as antimitotic agents | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2010-05-11 | — | — | US | disclosed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| WO-2010030787-A1 | ESTROGEN RECEPTOR LIGANDS | RADIUS HEALTH, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| US-20070265317-A1 | MODIFIED CHALCONE COMPOUNDS AS ANTIMITOTIC AGENTS | ARIZONA BIOMEDICAL RESEARCH COMMISSION (US) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265317-A1 | MODIFIED CHALCONE COMPOUNDS AS ANTIMITOTIC AGENTS | TUBA1C, SARS1, TUBB1 | TNFRSF1A 3293/4885CXCL12 3514/4885ABCG2 707/4885 |
| US-20100222380-A1 | Modified Chalcone Compounds as Antimitotic Agents | TUBA1C, SARS1, TUBB1 | TNFRSF1A 3373/4885CXCL12 3597/4885ABCG2 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.