Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261356 | 0.87 | CDK8 (0.44) | GAAPOLBMAPK10PIK3CAPRKDC | |
| SCHEMBL3262264 | 0.82 | TRIM24 (0.41) | GAAPOLBMAPK8MAPK10PIK3CA | |
| SCHEMBL3265734 | 0.73 | MEN1 (0.50) | MAPK10KDRMEN1KMT2AMAPT | |
| SCHEMBL28485324 | 0.72 | DEGS1 (0.40) | GAAPOLBPIK3CAKDRKMT2A | |
| SCHEMBL21386707 | 0.71 | MAPK10 (0.46) | POLBMAPK10PIK3CAPRKDCMAPT | |
| SCHEMBL3241851 | 0.70 | TEK (0.40) | POLBTEKMAPK10KDRMAPT | |
| SCHEMBL31737439 | 0.70 | ALDH5A1 (0.46) | MEN1KMT2A | |
| SCHEMBL3241814 | 0.69 | KDR (0.46) | POLBKDRMEN1KMT2AMAPT | |
| SCHEMBL31737159 | 0.69 | CDK6 (0.36) | DEGS1 | |
| SCHEMBL31737264 | 0.68 | GSK3B (0.45) | TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |