Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 6/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.57 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264207 | 0.80 | NUDT1 (0.72) | JAK1NUDT1EGLN2JAK3JAK2 | |
| SCHEMBL22499606 | 0.79 | NUDT1 (0.73) | JAK1NUDT1EGLN2JAK3LMNA | |
| SCHEMBL3657387 | 0.77 | JAK2 (0.61) | JAK1JAK3JAK2RAB9A | |
| SCHEMBL13072986 | 0.77 | JAK2 (0.76) | JAK1JAK3JAK2RAB9A | |
| SCHEMBL3601961 | 0.75 | NUDT1 (0.78) | JAK1NUDT1EGLN2JAK3JAK2 | |
| SCHEMBL3090231 | 0.75 | JAK1 (1.00) | JAK1NUDT1EGLN2JAK3JAK2 | |
| SCHEMBL3588844 | 0.73 | NUDT1 (0.57) | JAK1NUDT1EGLN2JAK3JAK2 | |
| SCHEMBL2250300 | 0.73 | NUDT1 (0.73) | JAK1NUDT1EGLN2JAK3JAK2 | |
| SCHEMBL2363033 | 0.73 | NUDT1 (0.73) | JAK1NUDT1EGLN2JAK3LMNA | |
| SCHEMBL2634912 | 0.73 | JAK3 (0.65) | JAK1NUDT1EGLN2JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |