Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 14/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152224 | 0.86 | CCKAR (0.64) | CCKARGABRA2GABRB2TGFBR1 | |
| SCHEMBL2152227 | 0.81 | CCKAR (0.68) | CCKAR | |
| SCHEMBL3125874 | 0.81 | CCKAR (0.80) | CCKAR | |
| SCHEMBL2152451 | 0.76 | CCKAR (0.63) | CCKARGABRA2GABRB2TGFBR1CTNNB1 | |
| SCHEMBL2152974 | 0.75 | CCKAR (0.70) | CCKAR | |
| SCHEMBL2152248 | 0.73 | GABRA2 (0.64) | CCKARGABRA2GABRB2TGFBR1 | |
| SCHEMBL13075589 | 0.73 | KDM4E (0.44) | CTNNB1WNT3A | |
| SCHEMBL5784967 | 0.71 | GABRA2 (0.57) | CCKARGABRA2GABRB2 | |
| SCHEMBL16574214 | 0.70 | NOTUM (0.50) | CTNNB1WNT3A | |
| SCHEMBL5781917 | 0.68 | GABRA2 (0.51) | CCKARGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010179-B1 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-07 | — | — | EP | disclosed |