Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 11/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.64 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.62 |
| ▸ | CCKAR | P32238 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152933 | 0.92 | GABRA2 (0.72) | GABRA2GABRB2TGFBR1CCKARNPC1 | |
| SCHEMBL2152224 | 0.86 | CCKAR (0.64) | GABRA2GABRB2TGFBR1CCKARNPC1 | |
| SCHEMBL5783286 | 0.78 | GABRA2 (0.80) | GABRA2GABRB2PTGS2MLYCD | |
| SCHEMBL2152521 | 0.78 | GABRA2 (0.75) | GABRA2GABRB2CCKAR | |
| SCHEMBL2152451 | 0.76 | CCKAR (0.63) | GABRA2GABRB2TGFBR1CCKARKDM4E | |
| SCHEMBL12510381 | 0.76 | CCKAR (0.52) | CCKARNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5784917 | 0.75 | GABRA2 (0.71) | GABRA2GABRB2TGFBR1PTGS2MLYCD | |
| SCHEMBL3125889 | 0.75 | CCKAR (1.00) | CCKAR | |
| SCHEMBL5423251 | 0.74 | GABRA2 (0.88) | GABRA2GABRB2KDM4EPTGS2MLYCD | |
| SCHEMBL2152523 | 0.73 | CCKAR (0.74) | CCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977339-B2 | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2010519-B1 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2011-07-06 | — | — | EP | disclosed |
| US-20100311649-A1 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | US | disclosed |
| US-7795265-B2 | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-09-14 | — | — | US | disclosed |
| US-7759352-B2 | Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-07-20 | — | — | US | disclosed |
| EP-2010179-B1 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-07 | — | — | EP | disclosed |
| US-20090281117-A1 | Substituted Imidazole-4-Carboxamides as Cholecystokinin -1 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2009-11-12 | — | — | US | disclosed |
| US-20090118300-A1 | Substituted Imidazole 4-Carboxamides as Cholecystokinin-1 Receptor Modulators | MERCK SHARP & DOHME LLC | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118300-A1 | Substituted Imidazole 4-Carboxamides as Cholecystokinin-1 Receptor Modulators | CCKAR, CCKBR, GPR119 | GABRA2 447/4885GABRB2 314/4885TGFBR1 1913/4885 |
| US-20090281117-A1 | Substituted Imidazole-4-Carboxamides as Cholecystokinin -1 Receptor Modulators | CCKAR, CCKBR, GPR119 | GABRA2 419/4885GABRB2 308/4885TGFBR1 1830/4885 |
| US-20100311649-A1 | SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS | CCKAR, CCKBR, GPR119 | GABRA2 447/4885GABRB2 314/4885TGFBR1 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.